4WV1

Crystal structure of the FGFR2 D2 domain in complex with Fab 2B.1.3

Summary for 4WV1

• Entry DOI: 10.2210/pdb4wv1/pdb
• Descriptor: Fibroblast growth factor receptor 2, Fab heavy chain, Fab light chain, ... (4 entities in total)
• Functional Keywords: fgfr2, fab, complex, antibody, transferase-immune system complex, transferase/immune system
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802
• Total number of polymer chains: 6
• Total formula weight: 118294.05

Authors

Yin, Y.,Carter, P.J. (deposition date: 2014-11-04, release date: 2015-09-16, Last modification date: 2023-09-27)

• Primary citation: Yin, Y.,Djakovic, S.,Marsters, S.,Tien, J.,Peng, J.,Tremayne, J.,Lee, G.,Neve, R.M.,Wu, Y.,Merchant, M.,Ashkenazi, A.,Carter, P.J.; Redesigning a Monospecific Anti-FGFR3 Antibody to Add Selectivity for FGFR2 and Expand Antitumor Activity.; Mol.Cancer Ther., 14:2270-2278, 2015; PubMed: 26269606; DOI: 10.1158/1535-7163.MCT-14-1050

Experimental method

X-RAY DIFFRACTION (2.362 Å)