4WUR

The crystal structure of the MERS-CoV papain-like protease (C111S) with human ubiquitin

4WUR の概要

• エントリーDOI: 10.2210/pdb4wur/pdb
• 関連するPDBエントリー: 4P16
• 分子名称: Papain-like protease, Polyubiquitin-B, ISOPROPYL ALCOHOL, ... (4 entities in total)
• 機能のキーワード: mers-cov, papain-like protease, ubiquitin, complex, hydrolase
• 由来する生物種: Human coronavirus EMC (HCoV-EMC); 詳細
• 細胞内の位置: Papain-like proteinase: Host membrane; Multi-pass membrane protein. Non-structural protein 4: Host membrane; Multi-pass membrane protein. Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region . Helicase: Host endoplasmic reticulum-Golgi intermediate compartment . Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region : K9N7C7; Ubiquitin: Cytoplasm : P0CG47
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 44917.97

構造登録者

Lei, J.,Hilgenfeld, R. (登録日: 2014-11-03, 公開日: 2014-11-26, 最終更新日: 2024-01-10)

• 主引用文献: Lei, J.,Hilgenfeld, R.; Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin.; Virol Sin, 31:288-299, 2016; PubMed: 27245450; DOI: 10.1007/s12250-016-3742-4

実験手法

X-RAY DIFFRACTION (3.16 Å)