4WT8

Crystal Structure of bactobolin A bound to 70S ribosome-tRNA complex

これはPDB形式変換不可エントリーです。

4WT8 の概要

• エントリーDOI: 10.2210/pdb4wt8/pdb
• 分子名称: mRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... (67 entities in total)
• 機能のキーワード: ribosome
• 由来する生物種: Thermus thermophilus; 詳細
• タンパク質・核酸の鎖数: 117
• 化学式量合計: 4460697.04

構造登録者

Amunts, A.,Fiedorczuk, K.,Ramakrishnan, V. (登録日: 2014-10-29, 公開日: 2015-01-21, 最終更新日: 2024-11-20)

主引用文献

Amunts, A.,Fiedorczuk, K.,Truong, T.T.,Chandler, J.,Peter Greenberg, E.,Ramakrishnan, V.
Bactobolin A Binds to a Site on the 70S Ribosome Distinct from Previously Seen Antibiotics.
J.Mol.Biol., 427:753-755, 2015

PubMed Abstract: The ribosome is the target of a large number of antibiotics. Here, we report a 3.4-Å-resolution crystal structure of bactobolin A bound to 70S ribosome-tRNA complex. The antibiotic binds at a previously unseen site in the 50S subunit and displaces tRNA bound at the P-site. It thus likely has a similar mechanism of action as blasticidin S despite binding to a different site. The structure also rationalizes previously identified resistance mutations.

PubMed: 25562208
DOI: 10.1016/j.jmb.2014.12.018

実験手法

X-RAY DIFFRACTION (3.4 Å)