4WSQ

Crystal Structure of Adaptor Protein 2 Associated Kinase (AAK1) in complex with small molecule inhibitor

Summary for 4WSQ

• Entry DOI: 10.2210/pdb4wsq/pdb
• Descriptor: AP2-associated protein kinase 1, ZINC ION, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: kinase, small-molecule, catalytic domain, protein kinase, protein binding, protein kinase inhibitors, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane ; Peripheral membrane protein : Q2M2I8
• Total number of polymer chains: 2
• Total formula weight: 72877.65

Authors

Sorrell, F.J.,Elkins, J.M.,Krojer, T.,Williams, E.,Abdul, K.,Gileadi, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2014-10-28, release date: 2014-11-05, Last modification date: 2024-01-10)

• Primary citation: Sorrell, F.J.,Szklarz, M.,Abdul Azeez, K.R.,Elkins, J.M.,Knapp, S.; Family-wide Structural Analysis of Human Numb-Associated Protein Kinases.; Structure, 24:401-411, 2016; PubMed: 26853940; DOI: 10.1016/j.str.2015.12.015

Experimental method

X-RAY DIFFRACTION (1.95 Å)