4WOI
4,5-linked aminoglycoside antibiotics regulate the bacterial ribosome by targeting dynamic conformational processes within intersubunit bridge B2
This is a non-PDB format compatible entry.
Summary for 4WOI
Entry DOI | 10.2210/pdb4woi/pdb |
Related | 4GAQ 4GAR 4GAS 4GAU |
Descriptor | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... (60 entities in total) |
Functional Keywords | protein biosynthesis, ribosomes, paromomycin, antibiotic translocation, rna, trna, transfer, exit, peptidyl, 30s, 70s, 16s, ribosomal subunit, ribosome |
Biological source | Escherichia coli str. K-12 substr. MDS42 More |
Total number of polymer chains | 110 |
Total formula weight | 4419077.67 |
Authors | Pulk, A.,Cate, J.H.D.,Blanchard, S.,Wasserman, M.,Altman, R.,Zhou, Z.,Zinder, J.,Green, K.,Garneau-Tsodikova, S. (deposition date: 2014-10-15, release date: 2015-08-05, Last modification date: 2023-12-27) |
Primary citation | Wasserman, M.R.,Pulk, A.,Zhou, Z.,Altman, R.B.,Zinder, J.C.,Green, K.D.,Garneau-Tsodikova, S.,Doudna Cate, J.H.,Blanchard, S.C. Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions. Nat Commun, 6:7896-7896, 2015 Cited by PubMed: 26224058DOI: 10.1038/ncomms8896 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
Download full validation report