4WNP
Structure of ULK1 bound to a potent inhibitor
Summary for 4WNP
Entry DOI | 10.2210/pdb4wnp/pdb |
Related | 4WNO |
Descriptor | Serine/threonine-protein kinase ULK1, GLYCEROL, N~2~-(1H-benzimidazol-6-yl)-N~4~-(5-cyclobutyl-1H-pyrazol-3-yl)quinazoline-2,4-diamine, ... (4 entities in total) |
Functional Keywords | kinase, autophagy, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytosol : O75385 |
Total number of polymer chains | 4 |
Total formula weight | 131051.03 |
Authors | Lazarus, M.B.,Novotny, C.J.,Shokat, K.M. (deposition date: 2014-10-14, release date: 2015-01-14, Last modification date: 2023-12-27) |
Primary citation | Lazarus, M.B.,Novotny, C.J.,Shokat, K.M. Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors. Acs Chem.Biol., 10:257-261, 2015 Cited by PubMed: 25551253DOI: 10.1021/cb500835z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.88 Å) |
Structure validation
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