4WNP

Structure of ULK1 bound to a potent inhibitor

Summary for 4WNP

• Entry DOI: 10.2210/pdb4wnp/pdb
• Related: 4WNO
• Descriptor: Serine/threonine-protein kinase ULK1, GLYCEROL, N~2~-(1H-benzimidazol-6-yl)-N~4~-(5-cyclobutyl-1H-pyrazol-3-yl)quinazoline-2,4-diamine, ... (4 entities in total)
• Functional Keywords: kinase, autophagy, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm, cytosol : O75385
• Total number of polymer chains: 4
• Total formula weight: 131051.03

Authors

Lazarus, M.B.,Novotny, C.J.,Shokat, K.M. (deposition date: 2014-10-14, release date: 2015-01-14, Last modification date: 2023-12-27)

• Primary citation: Lazarus, M.B.,Novotny, C.J.,Shokat, K.M.; Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors.; Acs Chem.Biol., 10:257-261, 2015; PubMed: 25551253; DOI: 10.1021/cb500835z

Experimental method

X-RAY DIFFRACTION (1.88 Å)