4WNP
Structure of ULK1 bound to a potent inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Serine/threonine-protein kinase ULK1 | polymer | 287 | 32320.3 | 4 | UniProt (O75385) Pfam (PF00069) In PDB | Homo sapiens (Human) | Autophagy-related protein 1 homolog,hATG1,Unc-51-like kinase 1 |
| 2 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 3 | A, B, C, D | N~2~-(1H-benzimidazol-6-yl)-N~4~-(5-cyclobutyl-1H-pyrazol-3-yl)quinazoline-2,4-diamine | non-polymer | 396.4 | 4 | Chemie (3RJ) | |||
| 4 | water | water | 18.0 | 243 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 283 (UniProt: O75385)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Ala 37 | Glu 37 | engineered mutation |
| Ala 38 | Lys 38 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 129281.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1770.0 | |
| All* | Total formula weight | 131051.0 |
