4WNK

Crystal Structure of Bovine G Protein Coupled-Receptor Kinase 5 in Complex with CCG215022

4WNK の概要

• エントリーDOI: 10.2210/pdb4wnk/pdb
• 関連するPDBエントリー: 3NYN 4MKO
• 分子名称: G protein-coupled receptor kinase 5, (4S)-4-{4-fluoro-3-[(pyridin-2-ylmethyl)carbamoyl]phenyl}-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: g protein-coupled receptor kinase 5, hydrolase, phosphorylation, cardiovascular disease, ligase
• 由来する生物種: Bos taurus (Bovine)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 69633.42

構造登録者

Homan, K.T.,Tesmer, J.J.G. (登録日: 2014-10-13, 公開日: 2015-06-10, 最終更新日: 2023-09-27)

• 主引用文献: Homan, K.T.,Waldschmidt, H.V.,Glukhova, A.,Cannavo, A.,Song, J.,Cheung, J.Y.,Koch, W.J.,Larsen, S.D.,Tesmer, J.J.; Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor.; J.Biol.Chem., 290:20649-20659, 2015; PubMed: 26032411; DOI: 10.1074/jbc.M115.647370

実験手法

X-RAY DIFFRACTION (2.42 Å)