4WNJ

Crystal structure of Transthyretin-quercetin complex

Summary for 4WNJ

• Entry DOI: 10.2210/pdb4wnj/pdb
• Descriptor: Transthyretin, DIMETHYL SULFOXIDE, 3,5,7,3',4'-PENTAHYDROXYFLAVONE, ... (4 entities in total)
• Functional Keywords: amyloidosis; protein misfolding, negative cooperativity, fibrillogenesis inhibitors, transthyretin stabilizers, transport protein
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted: P02766
• Total number of polymer chains: 2
• Total formula weight: 28013.22

Authors

Zanotti, G.,Cianci, M.,Berni, R.,Folli, C. (deposition date: 2014-10-13, release date: 2015-08-05, Last modification date: 2024-01-10)

• Primary citation: Cianci, M.,Folli, C.,Zonta, F.,Florio, P.,Berni, R.,Zanotti, G.; Structural evidence for asymmetric ligand binding to transthyretin.; Acta Crystallogr.,Sect.D, 71:1582-1592, 2015; PubMed: 26249340; DOI: 10.1107/S1399004715010585

Experimental method

X-RAY DIFFRACTION (1.398 Å)