4WMR

STRUCTURE OF MCL1 BOUND TO BRD inhibitor ligand 1 AT 1.7A

4WMR の概要

• エントリーDOI: 10.2210/pdb4wmr/pdb
• 関連するPDBエントリー: 4WMS 4WMT 4WMU 4WMV 4WMW 4WMX
• 分子名称: Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION, 7-[2-(1H-imidazol-1-yl)-4-methylpyridin-3-yl]-3-[3-(naphthalen-1-yloxy)propyl]-1-[2-oxo-2-(piperazin-1-yl)ethyl]-1H-indole-2-carboxylic acid, ... (5 entities in total)
• 機能のキーワード: apoptosis, protein-protein interaction, apoptosis-inhibitor complex, apoptosis/inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Membrane ; Single-pass membrane protein : Q07820
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18341.51

構造登録者

CLIFTON, M.C.,EDWARDS, T.E. (登録日: 2014-10-09, 公開日: 2015-05-06, 最終更新日: 2023-12-27)

• 主引用文献: Clifton, M.C.,Dranow, D.M.,Leed, A.,Fulroth, B.,Fairman, J.W.,Abendroth, J.,Atkins, K.A.,Wallace, E.,Fan, D.,Xu, G.,Ni, Z.J.,Daniels, D.,Van Drie, J.,Wei, G.,Burgin, A.B.,Golub, T.R.,Hubbard, B.K.,Serrano-Wu, M.H.; A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1.; Plos One, 10:e0125010-e0125010, 2015; PubMed: 25909780; DOI: 10.1371/journal.pone.0125010

実験手法

X-RAY DIFFRACTION (1.7 Å)