4WMR
STRUCTURE OF MCL1 BOUND TO BRD inhibitor ligand 1 AT 1.7A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 150 | 17164.6 | 1 | UniProt (Q07820) Pfam (PF00452) | Homo sapiens (Human) | Bcl-2-like protein 3,Bcl2-L-3,Bcl-2-related protein EAT/mcl1,mcl1/EAT |
| 2 | B, C, D (A) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 3 | E (A) | 7-[2-(1H-imidazol-1-yl)-4-methylpyridin-3-yl]-3-[3-(naphthalen-1-yloxy)propyl]-1-[2-oxo-2-(piperazin-1-yl)ethyl]-1H-indole-2-carboxylic acid | non-polymer | 628.7 | 1 | Chemie (865) PubChem (68937287) | |||
| 4 | F, G (A) | PYROPHOSPHATE 2- | non-polymer | 176.0 | 2 | Chemie (POP) PubChem (4995) | |||
| 5 | H (A) | water | water | 18.0 | 123 | Chemie (HOH) |
Sequence modifications
A: 173 - 321 (UniProt: Q07820)
| PDB | External Database | Details |
|---|---|---|
| Ser 172 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 17164.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1176.9 | |
| All* | Total formula weight | 18341.5 |
