4WLB

Crystal structure of RORc in complex with a partial inverse agonist compound

Summary for 4WLB

Entry DOI	10.2210/pdb4wlb/pdb
Descriptor	Nuclear receptor ROR-gamma, SRC-1 peptide, N-(4-fluorobenzyl)-N-(2-methylpropyl)-6-{[1-(methylsulfonyl)piperidin-4-yl]amino}pyridine-3-sulfonamide, ... (5 entities in total)
Functional Keywords	nuclear receptor ligand binding domain, transcription
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus : P51449
Total number of polymer chains	4
Total formula weight	64866.79
Authors	Boenig, G.,Hymowitz, S.G.,Kiefer, J.R. (deposition date: 2014-10-07, release date: 2014-11-12, Last modification date: 2023-12-27)
Primary citation	van Niel, M.B.,Fauber, B.P.,Cartwright, M.,Gaines, S.,Killen, J.C.,Rene, O.,Ward, S.I.,de Leon Boenig, G.,Deng, Y.,Eidenschenk, C.,Everett, C.,Gancia, E.,Ganguli, A.,Gobbi, A.,Hawkins, J.,Johnson, A.R.,Kiefer, J.R.,La, H.,Lockey, P.,Norman, M.,Ouyang, W.,Qin, A.,Wakes, N.,Waszkowycz, B.,Wong, H. A reversed sulfonamide series of selective RORc inverse agonists. Bioorg.Med.Chem.Lett., 24:5769-5776, 2014 Cited by PubMed: 25453817 DOI: 10.1016/j.bmcl.2014.10.037 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.702 Å)

Structure validation