4WKE
Crystal structure of human ADAMTS-4 in complex with inhibitor 5-chloro-N-{[(4R)-2,5-dioxo-4-(1,3-thiazol-2-yl)imidazolidin-4-yl]methyl}-1-benzofuran-2-carboxamide (compound 10)
Summary for 4WKE
| Entry DOI | 10.2210/pdb4wke/pdb |
| Related | 4WK7 4WKI |
| Descriptor | A disintegrin and metalloproteinase with thrombospondin motifs 4, ZINC ION, CALCIUM ION, ... (6 entities in total) |
| Functional Keywords | metalloprotease, osteoarthritis, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (Human) |
| Cellular location | Secreted, extracellular space, extracellular matrix : O75173 |
| Total number of polymer chains | 1 |
| Total formula weight | 26247.53 |
| Authors | Durbin, J.D. (deposition date: 2014-10-02, release date: 2014-12-10, Last modification date: 2023-12-27) |
| Primary citation | Durham, T.B.,Klimkowski, V.J.,Rito, C.J.,Marimuthu, J.,Toth, J.L.,Liu, C.,Durbin, J.D.,Stout, S.L.,Adams, L.,Swearingen, C.,Lin, C.,Chambers, M.G.,Thirunavukkarasu, K.,Wiley, M.R. Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis. J.Med.Chem., 57:10476-10485, 2014 Cited by PubMed: 25415648DOI: 10.1021/jm501522n PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.62 Å) |
Structure validation
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