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4WKE

Crystal structure of human ADAMTS-4 in complex with inhibitor 5-chloro-N-{[(4R)-2,5-dioxo-4-(1,3-thiazol-2-yl)imidazolidin-4-yl]methyl}-1-benzofuran-2-carboxamide (compound 10)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004222molecular_functionmetalloendopeptidase activity
A0006508biological_processproteolysis
A0008237molecular_functionmetallopeptidase activity
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 501
ChainResidue
AHIS361
AHIS365
AHIS371
A3PU508

site_idAC2
Number of Residues6
Detailsbinding site for residue CA A 502
ChainResidue
AHOH672
AGLU221
AASP304
AASP311
ACYS423
AASP426

site_idAC3
Number of Residues5
Detailsbinding site for residue CA A 503
ChainResidue
AGLU221
AASP304
AASP426
AHOH681
AHOH690

site_idAC4
Number of Residues6
Detailsbinding site for residue CA A 504
ChainResidue
AASP320
ALEU321
ACYS327
ATHR329
AGLU349
AHOH674

site_idAC5
Number of Residues5
Detailsbinding site for residue EDO A 505
ChainResidue
AGLN354
AALA396
AHIS397
AVAL398
AHOH606

site_idAC6
Number of Residues6
Detailsbinding site for residue EDO A 506
ChainResidue
AMET332
AALA333
AGLU362
AHIS365
A3PU508
AHOH725

site_idAC7
Number of Residues7
Detailsbinding site for residue EDO A 507
ChainResidue
AASP328
AVAL394
AMET395
A3PU508
AHOH732
AHOH758
AHOH763

site_idAC8
Number of Residues16
Detailsbinding site for residue 3PU A 508
ChainResidue
ATHR329
ALEU330
AGLY331
AMET332
AHIS361
AGLU362
AHIS365
AHIS371
AVAL390
AALA392
APRO393
AVAL394
AMET395
AZN501
AEDO506
AEDO507

Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAAHELGHVF
ChainResidueDetails
ATHR358-PHE367

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673
ChainResidueDetails
AGLU362

site_idSWS_FT_FI2
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:18042673
ChainResidueDetails
AHIS361
AHIS365
AHIS371

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PDB entries from 2024-07-31

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