4WGK

Crystal structure of human neutral ceramidase with Zn-bound phosphate

Summary for 4WGK

• Entry DOI: 10.2210/pdb4wgk/pdb
• Descriptor: Neutral ceramidase, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• Functional Keywords: ceramidase, amidase, zinc, phosphate, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 155831.60

Authors

Airola, M.V.,Pulkoski-Gross, M.J.,Obeid, L.M.,Hannun, Y.A. (deposition date: 2014-09-18, release date: 2015-07-08, Last modification date: 2023-09-27)

• Primary citation: Airola, M.V.,Allen, W.J.,Pulkoski-Gross, M.J.,Obeid, L.M.,Rizzo, R.C.,Hannun, Y.A.; Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase.; Structure, 23:1482-1491, 2015; PubMed: 26190575; DOI: 10.1016/j.str.2015.06.013

Experimental method

X-RAY DIFFRACTION (2.582 Å)