4WGK

Crystal structure of human neutral ceramidase with Zn-bound phosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0017040	molecular_function	N-acylsphingosine amidohydrolase activity
A	0046514	biological_process	ceramide catabolic process
B	0017040	molecular_function	N-acylsphingosine amidohydrolase activity
B	0046514	biological_process	ceramide catabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Region: {"description":"Required for correct folding and localization","evidences":[{"source":"UniProtKB","id":"Q91XT9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"16229686","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26190575","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WGK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"26190575","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WGK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (GalNAc...) threonine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---