4WEG

influenza virus neuraminidase N9 in complex 2,3-difluorosialic acid

Summary for 4WEG

• Entry DOI: 10.2210/pdb4weg/pdb
• Related: 1NNC 4WEF
• Descriptor: Neuraminidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: influenza virus neuraminidase, n9, complex, 2, 3-difluorosialic acid, second binding site, hydrolase
• Biological source: Influenza A virus (A/tern/Australia/G70C/1975(H11N9))
• Cellular location: Virion membrane : P03472
• Total number of polymer chains: 1
• Total formula weight: 46772.46

Authors

Streltsov, V.A.,Pilling, P.,Barrett, S.,McKimm-Breschkin, J. (deposition date: 2014-09-10, release date: 2015-09-16, Last modification date: 2020-07-29)

• Primary citation: Streltsov, V.A.,Pilling, P.,Barrett, S.,McKimm-Breschkin, J.L.; Catalytic mechanism and novel receptor binding sites of human parainfluenza virus type 3 hemagglutinin-neuraminidase (hPIV3 HN); Antiviral Res., 123:216-223, 2015; PubMed: 26364554; DOI: 10.1016/j.antiviral.2015.08.014

Experimental method

X-RAY DIFFRACTION (2.1 Å)