4WAB

Crystal structure of mPGES1 solved by native-SAD phasing

Summary for 4WAB

Entry DOI	10.2210/pdb4wab/pdb
Descriptor	Prostaglandin E synthase,Leukotriene C4 synthase, GLUTATHIONE, 2-[[2,6-bis(chloranyl)-3-[(2,2-dimethylpropanoylamino)methyl]phenyl]amino]-1-methyl-6-(2-methyl-2-oxidanyl-propoxy)-N-[2,2,2-tris(fluoranyl)ethyl]benzimidazole-5-carboxamide, ... (4 entities in total)
Functional Keywords	native-sad, isomerase, cancer, drug target, in meso crystallization, inflammation, inhibitor, leukotriene c4 synthase, lipid metabolism, membrane-associated proteins in eicosanoid and glutathione metabolism, mapag, membrane protein, mpges1, pain, microcrystal, anomalous dispersion, sulfur-sad, s-sad
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	21286.73
Authors	Weinert, T.,Li, D.,Howe, N.,Caffrey, M.,Wang, M. (deposition date: 2014-08-29, release date: 2014-12-10, Last modification date: 2015-02-11)
Primary citation	Weinert, T.,Olieric, V.,Waltersperger, S.,Panepucci, E.,Chen, L.,Zhang, H.,Zhou, D.,Rose, J.,Ebihara, A.,Kuramitsu, S.,Li, D.,Howe, N.,Schnapp, G.,Pautsch, A.,Bargsten, K.,Prota, A.E.,Surana, P.,Kottur, J.,Nair, D.T.,Basilico, F.,Cecatiello, V.,Pasqualato, S.,Boland, A.,Weichenrieder, O.,Wang, B.C.,Steinmetz, M.O.,Caffrey, M.,Wang, M. Fast native-SAD phasing for routine macromolecular structure determination. Nat.Methods, 12:131-133, 2015 Cited by PubMed: 25506719 DOI: 10.1038/nmeth.3211 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.704 Å)

Structure validation