4WAB
Crystal structure of mPGES1 solved by native-SAD phasing
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Prostaglandin E synthase,Leukotriene C4 synthase | polymer | 178 | 20360.9 | 1 | UniProt (O14684) UniProt (B5MCC3) Pfam (PF01124) UniProt (by SIFTS) (Q16873) In PDB | Homo sapiens (Human) | Microsomal glutathione S-transferase 1-like 1,MGST1-L1,Microsomal prostaglandin E synthase 1,MPGES-1,p53-induced gene 12 protein |
2 | A | GLUTATHIONE | non-polymer | 307.3 | 1 | Chemie (GSH) | |||
3 | A | 2-[[2,6-bis(chloranyl)-3-[(2,2-dimethylpropanoylamino)methyl]phenyl]amino]-1-methyl-6-(2-methyl-2-oxidanyl-propoxy)-N-[2,2,2-tris(fluoranyl)ethyl]benzimidazole-5-carboxamide | non-polymer | 618.5 | 1 | Chemie (LVJ) | |||
4 | water | water | 18.0 | 19 | Chemie (HOH) |
Sequence modifications
A: 10 - 151 (UniProt: O14684)
A: 152 - 172 (UniProt: B5MCC3)
PDB | External Database | Details |
---|---|---|
Met 3 | - | initiating methionine |
His 4 | - | expression tag |
His 5 | - | expression tag |
His 6 | - | expression tag |
His 7 | - | expression tag |
His 8 | - | expression tag |
His 9 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Arg 169 | Leu 90 | conflict |
Asp 173 | - | expression tag |
Tyr 174 | - | expression tag |
Lys 175 | - | expression tag |
Asp 176 | - | expression tag |
Asp 177 | - | expression tag |
Asp 178 | - | expression tag |
Asp 179 | - | expression tag |
Lys 180 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 20360.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 925.8 | |
All* | Total formula weight | 21286.7 |