4W9S
2-(4-(1H-tetrazol-5-yl)phenyl)-5-hydroxypyrimidin-4(3H)-one bound to influenza 2009 H1N1 endonuclease
Summary for 4W9S
Entry DOI | 10.2210/pdb4w9s/pdb |
Related | 4LN7 4M4Q 4M5O 4M5Q 4M5R 4M5U 4MK1 4MK2 4MK5 |
Descriptor | Polymerase acidic protein, MANGANESE (II) ION, SULFATE ION, ... (5 entities in total) |
Functional Keywords | cap-snatching, rna binding protein, rna binding protein-inhibitor complex, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Influenza A virus |
Cellular location | Host cytoplasm: P13166 |
Total number of polymer chains | 1 |
Total formula weight | 29063.49 |
Authors | Bauman, J.D.,Patel, D.,Das, K.,Arnold, E. (deposition date: 2014-08-27, release date: 2014-10-01, Last modification date: 2023-09-27) |
Primary citation | Sagong, H.Y.,Bauman, J.D.,Patel, D.,Das, K.,Arnold, E.,LaVoie, E.J. Phenyl Substituted 4-Hydroxypyridazin-3(2H)-ones and 5-Hydroxypyrimidin-4(3H)-ones: Inhibitors of Influenza A Endonuclease. J.Med.Chem., 57:8086-8098, 2014 Cited by PubMed: 25225968DOI: 10.1021/jm500958x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report