4W5Q

The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-8

Summary for 4W5Q

• Entry DOI: 10.2210/pdb4w5q/pdb
• Related: 4W5N 4W5O 4W5R 4W5T
• Descriptor: Protein argonaute-2, RNA (5'-R(P*UP*UP*CP*AP*CP*AP*UP*UP*GP*CP*CP*CP*AP*AP*GP*UP*CP*U)-3'), RNA (5'-R(*AP*AP*AP*UP*GP*UP*GP*AP*AP*A)-3'), ... (5 entities in total)
• Functional Keywords: ago2, guide, target, rnase, rnai, hydrolase-rna complex, hydrolase/rna
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm, P-body : Q9UKV8
• Total number of polymer chains: 3
• Total formula weight: 107937.64

Authors

Schirle, N.T.,MacRae, I.J. (deposition date: 2014-08-18, release date: 2014-11-12, Last modification date: 2023-09-27)

• Primary citation: Schirle, N.T.,Sheu-Gruttadauria, J.,MacRae, I.J.; Gene regulation. Structural basis for microRNA targeting.; Science, 346:608-613, 2014; PubMed: 25359968; DOI: 10.1126/science.1258040

Experimental method

X-RAY DIFFRACTION (3.101 Å)