4W5N
The Crystal Structure of Human Argonaute2 Bound to a Defined Guide RNA
Summary for 4W5N
Entry DOI | 10.2210/pdb4w5n/pdb |
Related | 4W5O 4W5Q 4W5R 4W5T |
Descriptor | Protein argonaute-2, RNA (5'-R(P*UP*UP*CP*AP*CP*AP*UP*UP*CP*AP*AP*GP*UP*CP*UP*CP*UP*U)-3'), PHENOL, ... (5 entities in total) |
Functional Keywords | ago2, rnase, rnai, rna, hydrolase-rna complex, hydrolase/rna |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm, P-body : Q9UKV8 |
Total number of polymer chains | 2 |
Total formula weight | 104232.69 |
Authors | Schirle, N.T.,Sheu-Gruttadauria, J.,MacRae, I.J. (deposition date: 2014-08-18, release date: 2014-11-12, Last modification date: 2023-09-27) |
Primary citation | Schirle, N.T.,Sheu-Gruttadauria, J.,MacRae, I.J. Gene regulation. Structural basis for microRNA targeting. Science, 346:608-613, 2014 Cited by PubMed: 25359968DOI: 10.1126/science.1258040 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
Download full validation report