4W4Z

Structure of the EphA4 LBD in complex with peptide

Summary for 4W4Z

• Entry DOI: 10.2210/pdb4w4z/pdb
• Related: 4W50
• Descriptor: Ephrin type-A receptor 4, APY-bAla8.am peptide, HEXANE-1,6-DIOL, ... (5 entities in total)
• Functional Keywords: protein-inhibitor complex, ligand binding domain, signal transduction, receptor-tyrosine kinase, cyclic peptide, epha4, phage display, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 89691.57

Authors

Lechtenberg, B.C.,Mace, P.D.,Riedl, S.J. (deposition date: 2014-08-15, release date: 2014-10-08, Last modification date: 2023-12-27)

• Primary citation: Lamberto, I.,Lechtenberg, B.C.,Olson, E.J.,Mace, P.D.,Dawson, P.E.,Riedl, S.J.,Pasquale, E.B.; Development and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor.; Acs Chem.Biol., 9:2787-2795, 2014; PubMed: 25268696; DOI: 10.1021/cb500677x

Experimental method

X-RAY DIFFRACTION (2.41 Å)