4V51
Structure of the Thermus thermophilus 70S ribosome complexed with mRNA, tRNA and paromomycin
This is a non-PDB format compatible entry.
Summary for 4V51
| Entry DOI | 10.2210/pdb4v51/pdb |
| Related | 1FJG 1GIX 1I94 1I95 1I96 1I97 1IBK 1IBL 1IBM 1J5E 1JGO 1JGP 1JGQ 1L1U 1N32 1N33 1N34 1N36 1PNS 1PNX 1XMO 1XMQ 1XNQ 1XNR 1YL4 2B64 2B9M 2B9O 2F4V |
| Descriptor | 16S ribosomal RNA, 30S RIBOSOMAL PROTEIN S10, 30S RIBOSOMAL PROTEIN S11, ... (58 entities in total) |
| Functional Keywords | ribosome, trna, paromomycin, mrna, translation |
| Biological source | THERMUS THERMOPHILUS More |
| Total number of polymer chains | 112 |
| Total formula weight | 4494240.86 |
| Authors | Selmer, M.,Dunham, C.M.,Murphy, F.V.,Weixlbaumer, A.,Petry, S.,Weir, J.R.,Kelley, A.C.,Ramakrishnan, V. (deposition date: 2006-07-31, release date: 2014-07-09, Last modification date: 2024-01-10) |
| Primary citation | Selmer, M.,Dunham, C.M.,Murphy, F.V.,Weixlbaumer, A.,Petry, S.,Kelley, A.C.,Weir, J.R.,Ramakrishnan, V. Structure of the 70S ribosome complexed with mRNA and tRNA. Science, 313:1935-1942, 2006 Cited by PubMed Abstract: The crystal structure of the bacterial 70S ribosome refined to 2.8 angstrom resolution reveals atomic details of its interactions with messenger RNA (mRNA) and transfer RNA (tRNA). A metal ion stabilizes a kink in the mRNA that demarcates the boundary between A and P sites, which is potentially important to prevent slippage of mRNA. Metal ions also stabilize the intersubunit interface. The interactions of E-site tRNA with the 50S subunit have both similarities and differences compared to those in the archaeal ribosome. The structure also rationalizes much biochemical and genetic data on translation. PubMed: 16959973DOI: 10.1126/science.1131127 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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