4V24

Sphingosine kinase 1 in complex with PF-543

Summary for 4V24

Entry DOI	10.2210/pdb4v24/pdb
Descriptor	SPHINGOSINE KINASE 1, {(2R)-1-[4-({3-METHYL-5-[(PHENYLSULFONYL)METHYL]PHENOXY}METHYL)BENZYL]PYRROLIDIN-2-YL}METHANOL, ACETATE ION, ... (4 entities in total)
Functional Keywords	transferase, sphk1, sphingosine, kinase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm: Q9NYA1
Total number of polymer chains	2
Total formula weight	83328.06
Authors	Elkins, J.M.,Wang, J.,Sorrell, F.,Tallant, C.,Wang, D.,Shrestha, L.,Bountra, C.,von Delft, F.,Knapp, S.,Edwards, A. (deposition date: 2014-10-05, release date: 2014-10-15, Last modification date: 2024-01-10)
Primary citation	Wang, J.,Knapp, S.,Pyne, N.J.,Pyne, S.,Elkins, J.M. Crystal Structure of Sphingosine Kinase 1 with Pf-543. Acs Med.Chem.Lett., 5:1329-, 2014 Cited by PubMed: 25516793 DOI: 10.1021/ML5004074 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation