4UZQ

STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH O-PALMITOLEOYL SERINE - CRYSTAL FORM IX - 1.5A

Summary for 4UZQ

Entry DOI	10.2210/pdb4uzq/pdb
Related	4UYU 4UYW 4UYZ 4UZ1 4UZ5 4UZ6 4UZ7 4UZ9 4UZA 4UZJ 4UZK 4UZL 4WBH
Descriptor	PROTEIN NOTUM HOMOLOG, PROTEIN WNT-7A, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	hydrolase, esterase, extracellular, alpha/beta hydrolase
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Secreted : Q6P988 Secreted, extracellular space, extracellular matrix: O00755
Total number of polymer chains	2
Total formula weight	45352.34
Authors	Zebisch, M.,Jones, E.Y. (deposition date: 2014-09-07, release date: 2015-02-25, Last modification date: 2020-07-29)
Primary citation	Kakugawa, S.,Langton, P.F.,Zebisch, M.,Howell, S.A.,Chang, T.,Liu, Y.,Feizi, T.,Bineva, G.,O'Reilly, N.,Snijders, A.P.,Jones, E.Y.,Vincent, J. Notum Deacylates Wnt Proteins to Suppress Signalling Activity. Nature, 519:187-, 2015 Cited by PubMed: 25731175 DOI: 10.1038/NATURE14259 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation