4UY9

Structure of MLK1 kinase domain with leucine zipper 1

Summary for 4UY9

Related4UYA
DescriptorMITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 9 (2 entities in total)
Functional Keywordsmlk family, mlk1 and mlk3 subtype, atp-binding, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, sh3 domain, transferase
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains2
Total molecular weight73232.26
Authors
Read, J.A.,Brassington, C.,Pollard, H.K.,Phillips, C.,Green, I.,Overmann, R.,Collier, M. (deposition date: 2014-08-29, release date: 2015-09-30, Last modification date: 2019-04-24)
Primary citation
Marusiak, A.A.,Stephenson, N.L.,Baik, H.,Trotter, E.W.,Li, Y.,Blyth, K.,Mason, S.,Chapman, P.,Puto, L.A.,Read, J.A.,Brassington, C.,Pollard, H.K.,Phillips, C.,Green, I.,Overman, R.,Collier, M.,Testoni, E.,Miller, C.,Hunter, T.,Sansom, O.J.,Brognard, J.
Recurrent Mlk4 Loss-of-Function Mutations Suppress Jnk Signaling to Promote Colon Tumorigenesis.
Cancer Res., 76:724-, 2016
PubMed: 26637668 (PDB entries with the same primary citation)
DOI: 10.1158/0008-5472.CAN-15-0701-T
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.81 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2354 1.4% 7.9% 0.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload