4UX4

Crystal structure of human tankyrase 2 in complex with 1-methyl-7-(4- methylphenyl)-5-oxo-5,6-dihydro-1,6-naphthyridin-1-ium

Summary for 4UX4

• Entry DOI: 10.2210/pdb4ux4/pdb
• Descriptor: TANKYRASE-2, (1S)-1-methyl-7-(4-methylphenyl)-5-oxo-1,5-dihydro-1,6-naphthyridin-1-ium, ZINC ION, ... (6 entities in total)
• Functional Keywords: transferase, diphtheria toxin like fold, adp- ribosylation, transferase-transferase inhibitor complex
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 55801.39

Authors

Haikarainen, T.,Lehtio, L. (deposition date: 2014-08-19, release date: 2015-06-10, Last modification date: 2019-02-06)

• Primary citation: Kumpan, K.,Nathubhai, A.,Zhang, C.,Wood, P.J.,Lloyd, M.D.,Thompson, A.S.,Haikarainen, T.,Lehtio, L.,Threadgill, M.D.; Structure-Based Design, Synthesis and Evaluation in Vitro of Arylnaphthyridinones, Arylpyridopyrimidinones and Their Tetrahydro Derivatives as Inhibitors of the Tankyrases.; Bioorg.Med.Chem., 23:3013-, 2015; PubMed: 26026769; DOI: 10.1016/J.BMC.2015.05.005

Experimental method

X-RAY DIFFRACTION (1.8 Å)