4UWY

FGFR1 Apo structure

Summary for 4UWY

• Entry DOI: 10.2210/pdb4uwy/pdb
• Related: 4UWZ 4UX0
• Descriptor: FIBROBLAST GROWTH FACTOR RECEPTOR 1, DI(HYDROXYETHYL)ETHER, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: transferase, inhibitor, drug, cancer, fgf, receptors, growth factors, signalling
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cell membrane; Single-pass type I membrane protein: P11362
• Total number of polymer chains: 2
• Total formula weight: 70829.70

Authors

Thiyagarajan, N.,Bunney, T.,Katan, M. (deposition date: 2014-08-15, release date: 2015-02-25, Last modification date: 2024-01-10)

• Primary citation: Bunney, T.,Wan, S.,Thiyagarajan, N.,Sutto, L.,Williams, S.V.,Ashford, P.,Koss, H.,Knowles, M.A.,Gervasio, F.L.,Coveney, P.V.,Katan, M.; The Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study; Ebiomedicine, 2:194-, 2015; PubMed: 26097890; DOI: 10.1016/J.EBIOM.2015.02.009

Experimental method

X-RAY DIFFRACTION (2.305 Å)