Summary for 5AM6
Entry DOI | 10.2210/pdb5am6/pdb |
Related | 5AM7 |
Descriptor | FIBROBLAST GROWTH FACTOR RECEPTOR 1, CHLORIDE ION, 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one, ... (4 entities in total) |
Functional Keywords | transferase, fgfr, growth factor, cancer, dovitinib, tki258, kinase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cell membrane; Single-pass type I membrane protein: P11362 |
Total number of polymer chains | 2 |
Total formula weight | 71508.44 |
Authors | Bunney, T.D.,Wan, S.,Thiyagarajan, N.,Sutto, L.,Williams, S.V.,Ashford, P.,Koss, H.,Knowles, M.A.,Gervasio, F.L.,Coveney, P.V.,Katan, M. (deposition date: 2015-03-10, release date: 2015-03-18, Last modification date: 2024-01-10) |
Primary citation | Bunney, T.,Wan, S.,Thiyagarajan, N.,Sutto, L.,Williams, S.V.,Ashford, P.,Koss, H.,Knowles, M.A.,Gervasio, F.L.,Coveney, P.V.,Katan, M. The Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study Ebiomedicine, 2:194-, 2015 Cited by PubMed: 26097890DOI: 10.1016/J.EBIOM.2015.02.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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