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5AM6

Native FGFR1 with an inhibitor

Replaces:  4UWZ
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BFIBROBLAST GROWTH FACTOR RECEPTOR 1polymer31035308.62UniProt (P11362)
Pfam (PF07714)
In PDB
HOMO SAPIENS (HUMAN)FGFR-1, FIBROBLAST GROWTH FACTOR 1, BASIC FIBROBLAST GROWTH FACTOR RECEPTOR FMS-LIKE TYROSINE KINASE 2, FLT-2, N-SAM, PROTO-ONCOGENE C-FGR, CD331
2ACHLORIDE IONnon-polymer35.53Chemie (CL)
3A, B4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-onenon-polymer392.42Chemie (38O)
4waterwater18.0256Chemie (HOH)
Sequence modifications
A, B: 458 - 765 (UniProt: P11362)
PDBExternal DatabaseDetails
Met 456-expression tag
Val 457-expression tag
Ala 488Cys 488conflict
Ser 584Cys 584conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight70617.2
Non-Polymers*Number of molecules5
Total formula weight891.2
All*Total formula weight71508.4
*Water molecules are not included.

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