4UWD
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) D315E VARIANT in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
Summary for 4UWD
Entry DOI | 10.2210/pdb4uwd/pdb |
Related | 3HQR 4BQX 4BQY |
Descriptor | EGL NINE HOMOLOG 1, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ... (4 entities in total) |
Functional Keywords | oxidoreductase, non-heme, iron, 2-oxoglutarate, dioxygenase, hypoxia-inducible factor, hif, hif prolyl hydroxylase domain 2, phd2, egln, oxygenase, hypoxia, dna-binding, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, asparaginyl/ aspartyl hydroxylase, transcription and epigenetic regulation, signaling, development, cell structure, ankyrin repeat domain, ard, beta-hydroxylation, transcription activator/inhibitor, phosphorylation, s-nitrosylation |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 28446.57 |
Authors | Chowdhury, R.,Tarhonskaya, H.,Schofield, C.J. (deposition date: 2014-08-11, release date: 2014-08-27, Last modification date: 2024-01-10) |
Primary citation | Tarhonskaya, H.,Chowdhury, R.,Leung, I.K.H.,Loik, N.D.,Mccullagh, J.S.O.,Claridge, T.D.W.,Schofield, C.J.,Flashman, E. Investigating the Contribution of the Active Site Environment to the Slow Reaction of Hypoxia-Inducible Factor Prolyl Hydroxylase Domain 2 with Oxygen. Biochem.J., 463:363-, 2014 Cited by PubMed: 25120187DOI: 10.1042/BJ20140779 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.721 Å) |
Structure validation
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