3HQR
PHD2:Mn:NOG:HIF1-alpha substrate complex
Summary for 3HQR
Entry DOI | 10.2210/pdb3hqr/pdb |
Related | 2G1M 3HQU |
Descriptor | Egl nine homolog 1, Hypoxia-inducible factor 1 alpha, MANGANESE (II) ION, ... (5 entities in total) |
Functional Keywords | double stranded beta-helix, alternative splicing, congenital erythrocytosis, dioxygenase, disease mutation, iron, metal-binding, oxidoreductase, vitamin c, zinc, zinc-finger, activator, cytoplasm, dna-binding, hydroxylation, isopeptide bond, nucleus, phosphoprotein, polymorphism, s-nitrosylation, transcription, transcription regulation, ubl conjugation, oxidoreductase-transcription complex, oxidoreductase/transcription |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm : Q9GZT9 Q16665 |
Total number of polymer chains | 2 |
Total formula weight | 29667.51 |
Authors | Chowdhury, R.,McDonough, M.A.,Schofield, C.J. (deposition date: 2009-06-08, release date: 2009-07-28, Last modification date: 2023-11-01) |
Primary citation | Chowdhury, R.,McDonough, M.A.,Mecinovic, J.,Loenarz, C.,Flashman, E.,Hewitson, K.S.,Domene, C.,Schofield, C.J. Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases Structure, 17:981-989, 2009 Cited by PubMed: 19604478DOI: 10.1016/j.str.2009.06.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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