4UVA

LSD1(KDM1A)-CoREST in complex with 1-Methyl-Tranylcypromine (1R,2S)

4UVA の概要

• エントリーDOI: 10.2210/pdb4uva/pdb
• 関連するPDBエントリー: 4UV8 4UV9 4UVB 4UVC
• 分子名称: LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(4aS)-4a-[(1S,3E)-3-imino-1-phenylbutyl]-7,8-dimethyl-2,4-dioxo-3,4,4a,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]pentyl dihydrogen diphosphate, ... (4 entities in total)
• 機能のキーワード: transcription, covalent inhibitor
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Nucleus: O60341 Q9UKL0
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 148880.96

構造登録者

Vianello, P.,Botrugno, O.,Cappa, A.,Ciossani, G.,Dessanti, P.,Mai, A.,Mattevi, A.,Meroni, G.,Minucci, S.,Thaler, F.,Tortorici, M.,Trifiro, P.,Valente, S.,Villa, M.,Varasi, M.,Mercurio, C. (登録日: 2014-08-05, 公開日: 2014-09-10, 最終更新日: 2024-01-10)

• 主引用文献: Vianello, P.,Botrugno, O.A.,Cappa, A.,Ciossani, G.,Dessanti, P.,Mai, A.,Mattevi, A.,Meroni, G.,Minucci, S.,Thaler, F.,Tortorici, M.,Trifiro, P.,Valente, S.,Villa, M.,Varasi, M.,Mercurio, C.; Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A.; Eur.J.Med.Chem., 86C:352-, 2014; PubMed: 25173853; DOI: 10.1016/J.EJMECH.2014.08.068

実験手法

X-RAY DIFFRACTION (2.9 Å)