4UHX

Human aldehyde oxidase in complex with phthalazine and thioridazine

Summary for 4UHX

• Entry DOI: 10.2210/pdb4uhx/pdb
• Related: 4UHW
• Descriptor: ALDEHYDE OXIDASE, FE2/S2 (INORGANIC) CLUSTER, PHOSPHONIC ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER, ... (10 entities in total)
• Functional Keywords: oxidoreductase, aldehyde oxidase, drug metabolism, molybdenum enzymes, xanthine oxidase, phthalazine, thioridazine
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm : Q06278
• Total number of polymer chains: 1
• Total formula weight: 150865.44

Authors

Coelho, C.,Romao, M.J.,Santos-Silva, T. (deposition date: 2015-03-26, release date: 2015-09-02, Last modification date: 2024-01-10)

• Primary citation: Coelho, C.,Foti, A.,Hartmann, T.,Santos-Silva, T.,Leimkuhler, S.,Romao, M.J.; Structural Insights Into Xenobiotic and Inhibitor Binding to Human Aldehyde Oxidase; Nat.Chem.Biol., 11:779-, 2015; PubMed: 26322824; DOI: 10.1038/NCHEMBIO.1895

Experimental method

X-RAY DIFFRACTION (2.7 Å)