4UHI

HUMAN STEROL 14-ALPHA DEMETHYLASE (CYP51) IN COMPLEX WITH VFV IN C121 SPACE GROUP

Summary for 4UHI

Entry DOI	10.2210/pdb4uhi/pdb
Related	4UHL
Descriptor	STEROL 14-ALPHA DEMETHYLASE, PROTOPORPHYRIN IX CONTAINING FE, N-[(1R)-1-(3,4'-difluorobiphenyl-4-yl)-2-(1H-imidazol-1-yl)ethyl]-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide, ... (4 entities in total)
Functional Keywords	oxidoreductase, monooxygenase, sterol biosynthesis, eukaryotic membranes, cytochrome p450 fold, endoplasmic reticulum
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	4
Total formula weight	209859.00
Authors	Hargrove, T.Y.,Wawrzak, Z.,I Lepesheva, G. (deposition date: 2015-03-24, release date: 2016-06-08, Last modification date: 2018-06-20)
Primary citation	Hargrove, T.Y.,Friggeri, L.,Wawrzak, Z.,Sivakumaran, S.,Yazlovitskaya, E.M.,Hiebert, S.W.,Guengerich, F.P.,Waterman, M.R.,Lepesheva, G.I. Human Sterol 14Alpha-Demethylase (Cyp51) as a Target for Anticancer Chemotherapy: Towards Structure-Aided Drug Design. J.Lipid Res., 57:1552-, 2016 Cited by PubMed: 27313059 DOI: 10.1194/JLR.M069229 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.04 Å)

Structure validation