4UHL

HUMAN STEROL 14-ALPHA DEMETHYLASE (CYP51) IN COMPLEX WITH VFV IN P1 SPACE GROUP

Summary for 4UHL

• Entry DOI: 10.2210/pdb4uhl/pdb
• Related: 4UHI
• Descriptor: STEROL 14-ALPHA DEMETHYLASE, PROTOPORPHYRIN IX CONTAINING FE, N-[(1R)-1-(3,4'-difluorobiphenyl-4-yl)-2-(1H-imidazol-1-yl)ethyl]-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide, ... (4 entities in total)
• Functional Keywords: cytochrome p450, cyp51, oxidoreductase, monooxygenase, sterol biosynthesis, eukaryotic membranes, cytochrome p450 fold, endoplasmic reticulum
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Endoplasmic reticulum membrane : Q16850
• Total number of polymer chains: 8
• Total formula weight: 422113.07

Authors

Hargrove, T.Y.,Wawrzak, Z.,I Lepesheva, G. (deposition date: 2015-03-24, release date: 2016-06-15, Last modification date: 2024-01-10)

• Primary citation: Hargrove, T.Y.,Friggeri, L.,Wawrzak, Z.,Sivakumaran, S.,Yazlovitskaya, E.M.,Hiebert, S.W.,Guengerich, F.P.,Waterman, M.R.,Lepesheva, G.I.; Human Sterol 14Alpha-Demethylase (Cyp51) as a Target for Anticancer Chemotherapy: Towards Structure-Aided Drug Design.; J.Lipid Res., 57:1552-, 2016; PubMed: 27313059; DOI: 10.1194/JLR.M069229

Experimental method

X-RAY DIFFRACTION (2.5 Å)