Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0020037 | molecular_function | heme binding |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| B | 0020037 | molecular_function | heme binding |
| C | 0004497 | molecular_function | monooxygenase activity |
| C | 0005506 | molecular_function | iron ion binding |
| C | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| C | 0020037 | molecular_function | heme binding |
| D | 0004497 | molecular_function | monooxygenase activity |
| D | 0005506 | molecular_function | iron ion binding |
| D | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| D | 0020037 | molecular_function | heme binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE HEM A 540 |
| Chain | Residue |
| A | TYR145 |
| A | PRO441 |
| A | PHE442 |
| A | GLY443 |
| A | HIS447 |
| A | CYS449 |
| A | ILE450 |
| A | GLY451 |
| A | ALA455 |
| A | VFV580 |
| A | HOH2203 |
| A | PHE152 |
| A | LYS156 |
| A | ALA311 |
| A | THR315 |
| A | PRO376 |
| A | ILE377 |
| A | MET380 |
| A | ARG382 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE VFV A 580 |
| Chain | Residue |
| A | TYR131 |
| A | LEU134 |
| A | THR135 |
| A | PHE139 |
| A | PHE152 |
| A | LEU159 |
| A | PHE234 |
| A | TRP239 |
| A | MET304 |
| A | GLY307 |
| A | LEU308 |
| A | LEU310 |
| A | ALA311 |
| A | ILE377 |
| A | MET487 |
| A | HEM540 |
| A | VFV600 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE VFV A 600 |
| Chain | Residue |
| A | PHE77 |
| A | MET100 |
| A | VAL101 |
| A | PHE105 |
| A | TYR107 |
| A | HIS236 |
| A | TRP239 |
| A | ILE379 |
| A | MET381 |
| A | VFV580 |
| A | HOH2117 |
| A | HOH2222 |
| B | LEU245 |
| B | PRO246 |
| B | LEU247 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE HEM B 540 |
| Chain | Residue |
| B | TYR145 |
| B | PHE152 |
| B | LYS156 |
| B | ALA311 |
| B | THR315 |
| B | PRO376 |
| B | ILE377 |
| B | MET380 |
| B | ARG382 |
| B | PRO441 |
| B | PHE442 |
| B | GLY443 |
| B | HIS447 |
| B | CYS449 |
| B | GLY451 |
| B | VFV580 |
| B | HOH2047 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE VFV B 580 |
| Chain | Residue |
| B | TYR131 |
| B | LEU134 |
| B | PHE139 |
| B | ALA144 |
| B | LEU159 |
| B | PHE234 |
| B | SER235 |
| B | HIS236 |
| B | TRP239 |
| B | MET304 |
| B | GLY307 |
| B | LEU308 |
| B | ALA311 |
| B | THR315 |
| B | ILE377 |
| B | HEM540 |
| B | VFV600 |
| B | HOH2040 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE VFV B 600 |
| Chain | Residue |
| B | HOH2092 |
| B | HOH2179 |
| B | HOH2180 |
| A | LEU245 |
| A | PRO246 |
| A | LEU247 |
| B | PHE77 |
| B | MET100 |
| B | VAL101 |
| B | PHE105 |
| B | TYR107 |
| B | HIS236 |
| B | TRP239 |
| B | ILE379 |
| B | MET381 |
| B | VFV580 |
| site_id | AC7 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE HEM C 540 |
| Chain | Residue |
| C | TYR145 |
| C | PHE152 |
| C | LYS156 |
| C | ALA311 |
| C | THR315 |
| C | PRO376 |
| C | ILE377 |
| C | MET380 |
| C | ARG382 |
| C | PRO441 |
| C | PHE442 |
| C | GLY443 |
| C | HIS447 |
| C | CYS449 |
| C | ILE450 |
| C | GLY451 |
| C | ALA455 |
| C | VFV580 |
| C | HOH2028 |
| C | HOH2115 |
| site_id | AC8 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE VFV C 580 |
| Chain | Residue |
| C | TYR131 |
| C | LEU134 |
| C | PHE139 |
| C | ALA144 |
| C | PHE152 |
| C | LEU159 |
| C | PHE234 |
| C | TRP239 |
| C | MET304 |
| C | GLY307 |
| C | LEU310 |
| C | ALA311 |
| C | THR315 |
| C | ILE377 |
| C | HEM540 |
| C | VFV600 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE VFV C 600 |
| Chain | Residue |
| C | PHE77 |
| C | MET100 |
| C | VAL101 |
| C | PHE105 |
| C | TYR107 |
| C | HIS236 |
| C | TRP239 |
| C | ILE379 |
| C | MET381 |
| C | ILE488 |
| C | VFV580 |
| C | HOH2131 |
| D | PRO246 |
| D | LEU247 |
| site_id | BC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE HEM D 540 |
| Chain | Residue |
| D | TYR145 |
| D | PHE152 |
| D | LYS156 |
| D | ALA311 |
| D | GLY312 |
| D | THR315 |
| D | PRO376 |
| D | ILE377 |
| D | MET380 |
| D | ARG382 |
| D | PRO441 |
| D | PHE442 |
| D | GLY443 |
| D | HIS447 |
| D | CYS449 |
| D | ILE450 |
| D | GLY451 |
| D | ALA455 |
| D | VFV580 |
| site_id | BC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE VFV D 580 |
| Chain | Residue |
| D | LEU134 |
| D | PHE139 |
| D | LEU159 |
| D | PHE234 |
| D | TRP239 |
| D | MET304 |
| D | GLY307 |
| D | LEU308 |
| D | LEU310 |
| D | ALA311 |
| D | ILE377 |
| D | HEM540 |
| D | VFV600 |
| D | HOH2120 |
| site_id | BC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE VFV D 600 |
| Chain | Residue |
| C | LEU245 |
| C | PRO246 |
| C | LEU247 |
| D | PHE77 |
| D | MET100 |
| D | VAL101 |
| D | PHE105 |
| D | TYR107 |
| D | HIS236 |
| D | TRP239 |
| D | LEU240 |
| D | ILE379 |
| D | MET381 |
| D | ILE488 |
| D | VFV580 |
| D | HOH2121 |
Functional Information from PROSITE/UniProt
| site_id | PS00086 |
| Number of Residues | 10 |
| Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGaGRHRCIG |
| Chain | Residue | Details |
| A | PHE442-GLY451 | |
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTASHC |
| Chain | Residue | Details |
| A | LEU204-CYS209 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"20149798","evidenceCode":"ECO:0000269"}]} |
