4UHI

HUMAN STEROL 14-ALPHA DEMETHYLASE (CYP51) IN COMPLEX WITH VFV IN C121 SPACE GROUP

Summary for 4UHI

Related4UHL
DescriptorSTEROL 14-ALPHA DEMETHYLASE, PROTOPORPHYRIN IX CONTAINING FE, N-[(1R)-1-(3,4'-difluorobiphenyl-4-yl)-2-(1H-imidazol-1-yl)ethyl]-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide, ... (4 entities in total)
Functional Keywordsoxidoreductase, monooxygenase, sterol biosynthesis, eukaryotic membranes, cytochrome p450 fold, endoplasmic reticulum
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains4
Total molecular weight209859
Authors
Hargrove, T.Y.,Wawrzak, Z.,I Lepesheva, G. (deposition date: 2015-03-24, release date: 2016-06-08, Last modification date: 2018-06-20)
Primary citation
Hargrove, T.Y.,Friggeri, L.,Wawrzak, Z.,Sivakumaran, S.,Yazlovitskaya, E.M.,Hiebert, S.W.,Guengerich, F.P.,Waterman, M.R.,Lepesheva, G.I.
Human Sterol 14Alpha-Demethylase (Cyp51) as a Target for Anticancer Chemotherapy: Towards Structure-Aided Drug Design.
J.Lipid Res., 57:1552-, 2016
PubMed: 27313059 (PDB entries with the same primary citation)
DOI: 10.1194/JLR.M069229
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.04 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.242700.1%0.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload