4UHI

HUMAN STEROL 14-ALPHA DEMETHYLASE (CYP51) IN COMPLEX WITH VFV IN C121 SPACE GROUP

4UHI の概要

• エントリーDOI: 10.2210/pdb4uhi/pdb
• 関連するPDBエントリー: 4UHL
• 分子名称: STEROL 14-ALPHA DEMETHYLASE, PROTOPORPHYRIN IX CONTAINING FE, N-[(1R)-1-(3,4'-difluorobiphenyl-4-yl)-2-(1H-imidazol-1-yl)ethyl]-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, monooxygenase, sterol biosynthesis, eukaryotic membranes, cytochrome p450 fold, endoplasmic reticulum
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 209859.00

構造登録者

Hargrove, T.Y.,Wawrzak, Z.,I Lepesheva, G. (登録日: 2015-03-24, 公開日: 2016-06-08, 最終更新日: 2018-06-20)

• 主引用文献: Hargrove, T.Y.,Friggeri, L.,Wawrzak, Z.,Sivakumaran, S.,Yazlovitskaya, E.M.,Hiebert, S.W.,Guengerich, F.P.,Waterman, M.R.,Lepesheva, G.I.; Human Sterol 14Alpha-Demethylase (Cyp51) as a Target for Anticancer Chemotherapy: Towards Structure-Aided Drug Design.; J.Lipid Res., 57:1552-, 2016; PubMed: 27313059; DOI: 10.1194/JLR.M069229

実験手法

X-RAY DIFFRACTION (2.04 Å)