4UER

40S-eIF1-eIF1A-eIF3-eIF3j translation initiation complex from Lachancea kluyveri

4UER の概要

• エントリーDOI: 10.2210/pdb4uer/pdb
• EMDBエントリー: 2845
• 分子名称: EIF1A, ES31, 18S RRNA, ... (40 entities in total)
• 機能のキーワード: eif3, translation initiation, translation
• 由来する生物種: LACHANCEA KLUYVERI; 詳細
• タンパク質・核酸の鎖数: 39
• 化学式量合計: 1428954.99

構造登録者

Aylett, C.H.S.,Boehringer, D.,Erzberger, J.P.,Schaefer, T.,Ban, N. (登録日: 2014-12-18, 公開日: 2015-02-11, 最終更新日: 2024-05-08)

主引用文献

Aylett, C.H.S.,Boehringer, D.,Erzberger, J.P.,Schaefer, T.,Ban, N.
Structure of a Yeast 40S-Eif1-Eif1A-Eif3-Eif3J Initiation Complex
Nat.Struct.Mol.Biol., 22:269-, 2015

PubMed Abstract: Eukaryotic translation initiation requires cooperative assembly of a large protein complex at the 40S ribosomal subunit. We have resolved a budding yeast initiation complex by cryo-EM, allowing placement of prior structures of eIF1, eIF1A, eIF3a, eIF3b and eIF3c. Our structure highlights differences in initiation-complex binding to the ribosome compared to that of mammalian eIF3, demonstrates a direct contact between eIF3j and eIF1A and reveals the network of interactions between eIF3 subunits.

PubMed: 25664723
DOI: 10.1038/NSMB.2963

実験手法

ELECTRON MICROSCOPY (6.47 Å)