4UCH
Structure of human nNOS R354A G357D mutant heme domain in complex with 3-(((2-((2-(1H-IMIDAZOL-1-YL)PYRIMIDIN-4-YL)ETHYL)AMINO)METHYL) BENZONITRILE
Summary for 4UCH
Entry DOI | 10.2210/pdb4uch/pdb |
Descriptor | NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (6 entities in total) |
Functional Keywords | oxidoreductase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cell membrane, sarcolemma; Peripheral membrane protein: P29475 |
Total number of polymer chains | 2 |
Total formula weight | 100072.67 |
Authors | Li, H.,Poulos, T.L. (deposition date: 2014-12-03, release date: 2014-12-24, Last modification date: 2023-12-20) |
Primary citation | Mukherjee, P.,Li, H.,Sevrioukova, I.,Chreifi, G.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase. J.Med.Chem., 58:1067-, 2015 Cited by PubMed: 25489882DOI: 10.1021/JM501719E PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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