4U7Q
Structure of wild-type HIV protease in complex with photosensitive inhibitor PDI-6
Summary for 4U7Q
Entry DOI | 10.2210/pdb4u7q/pdb |
Related | 4U7V |
Descriptor | V-1 protease, N~2~-({[7-(diethylamino)-2-oxo-2H-chromen-4-yl]methoxy}carbonyl)-N-[(2S,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-L-valinamide (3 entities in total) |
Functional Keywords | hiv-1, viral protease, aspartic protease, inhibition, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22407.58 |
Authors | Pachl, P.,Rezacova, P.,Schimer, J. (deposition date: 2014-07-31, release date: 2015-03-25, Last modification date: 2023-12-20) |
Primary citation | Schimer, J.,Pavova, M.,Anders, M.,Pachl, P.,Sacha, P.,Cigler, P.,Weber, J.,Majer, P.,Rezacova, P.,Krausslich, H.G.,Muller, B.,Konvalinka, J. Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor. Nat Commun, 6:6461-6461, 2015 Cited by PubMed: 25751579DOI: 10.1038/ncomms7461 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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