4U5W

Crystal Structure of HIV-1 Nef-SF2 Core Domain in Complex with the Src Family Kinase Hck SH3-SH2 Tandem Regulatory Domains

4U5W の概要

• エントリーDOI: 10.2210/pdb4u5w/pdb
• 分子名称: Protein Nef, Tyrosine-protein kinase HCK, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (5 entities in total)
• 機能のキーワード: hck, sh3-sh2 regulatory domains, sh3, sh2, src family kinase, sfk, hiv-1, nef, virus, protein-protein complex, nef-hck complex, viral protein-transferase complex, viral protein/transferase
• 由来する生物種: Human immunodeficiency virus type 1 (HIV-1); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 77786.27

構造登録者

Alvarado, J.J.,Yeh, J.I.,Smithgall, T.E. (登録日: 2014-07-25, 公開日: 2014-08-20, 最終更新日: 2023-09-27)

• 主引用文献: Alvarado, J.J.,Tarafdar, S.,Yeh, J.I.,Smithgall, T.E.; Interaction with the Src Homology (SH3-SH2) Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment.; J.Biol.Chem., 289:28539-28553, 2014; PubMed: 25122770; DOI: 10.1074/jbc.M114.600031

実験手法

X-RAY DIFFRACTION (1.86 Å)