4TZC

Crystal Structure of Murine Cereblon in Complex with Thalidomide

Summary for 4TZC

• Entry DOI: 10.2210/pdb4tzc/pdb
• Descriptor: Protein cereblon, ZINC ION, S-Thalidomide, ... (5 entities in total)
• Functional Keywords: ubiquitin ligase, dcaf, ligase
• Biological source: Mus musculus (Mouse)
• Cellular location: Cytoplasm : Q8C7D2
• Total number of polymer chains: 4
• Total formula weight: 50294.70

Authors

Chamberlain, P.P.,Pagarigan, B.,Delker, S.,Leon, B. (deposition date: 2014-07-10, release date: 2014-08-06, Last modification date: 2023-12-27)

• Primary citation: Chamberlain, P.P.,Lopez-Girona, A.,Miller, K.,Carmel, G.,Pagarigan, B.,Leon, B.,Rychak, E.,Corral, L.,Ren, Y.,Wang, M.,Riley, M.,Delker, S.,Ito, T.,Hideki, A.,Mori, T.,Hirano, Y.,Handa, H.,Hakoshima, T.,Daniel, T.O.,Cathers, B.E.; Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex; to be published,

Experimental method

X-RAY DIFFRACTION (1.88 Å)