4TY0

Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase in complex with linear intermediate 5' pppA(3',5')pG

4TY0 の概要

• エントリーDOI: 10.2210/pdb4ty0/pdb
• 分子名称: Cyclic AMP-GMP synthase, MAGNESIUM ION, [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3-[[(2R,3S,4R,5R)-5-(2-azanyl-6-oxidanylidene-3H-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-4-oxidanyl-oxolan-2-yl]methoxy-[[oxidanyl(phosphonooxy)phosphoryl]methyl]phosphinic acid, ... (5 entities in total)
• 機能のキーワード: nucleotidyl transferase, cyclic nucleotide synthase, cgas, transferase
• 由来する生物種: Vibrio cholerae O1 biovar El Tor str. N16961
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 95907.80

構造登録者

Kranzusch, P.J.,Lee, A.S.Y.,Wilson, S.C.,Solovykh, M.S.,Vance, R.E.,Berger, J.M.,Doudna, J.A. (登録日: 2014-07-07, 公開日: 2014-08-13, 最終更新日: 2023-12-27)

• 主引用文献: Kranzusch, P.J.,Lee, A.S.,Wilson, S.C.,Solovykh, M.S.,Vance, R.E.,Berger, J.M.,Doudna, J.A.; Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity.; Cell, 158:1011-1021, 2014; PubMed: 25131990; DOI: 10.1016/j.cell.2014.07.028

実験手法

X-RAY DIFFRACTION (1.8 Å)