4TWT
Human TNFa dimer in complex with the semi-synthetic bicyclic peptide M21
Summary for 4TWT
Entry DOI | 10.2210/pdb4twt/pdb |
Descriptor | Tumor necrosis factor, ALA-CYS-PRO-PRO-CYS-LEU-TRP-GLN-VAL-LEU-CYS-GLY, GLYCEROL, ... (5 entities in total) |
Functional Keywords | tumor necrosis factor-alpha, bicyclo compounds, peptides, cytokine-inhibitor complex, cytokine/inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane ; Single-pass type II membrane protein . Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted. C-domain 1: Secreted. C-domain 2: Secreted: P01375 |
Total number of polymer chains | 6 |
Total formula weight | 73034.91 |
Authors | Luzi, S.,Kondo, Y.,Bernard, E.,Stadler, L.,Winter, G.,Holliger, P. (deposition date: 2014-07-01, release date: 2015-02-04, Last modification date: 2023-12-20) |
Primary citation | Luzi, S.,Kondo, Y.,Bernard, E.,Stadler, L.K.,Vaysburd, M.,Winter, G.,Holliger, P. Subunit disassembly and inhibition of TNF alpha by a semi-synthetic bicyclic peptide. Protein Eng.Des.Sel., 28:45-52, 2015 Cited by PubMed: 25614525DOI: 10.1093/protein/gzu055 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
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