4TWT

Human TNFa dimer in complex with the semi-synthetic bicyclic peptide M21

4TWT の概要

• エントリーDOI: 10.2210/pdb4twt/pdb
• 分子名称: Tumor necrosis factor, ALA-CYS-PRO-PRO-CYS-LEU-TRP-GLN-VAL-LEU-CYS-GLY, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: tumor necrosis factor-alpha, bicyclo compounds, peptides, cytokine-inhibitor complex, cytokine/inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane ; Single-pass type II membrane protein . Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted. C-domain 1: Secreted. C-domain 2: Secreted: P01375
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 73034.91

構造登録者

Luzi, S.,Kondo, Y.,Bernard, E.,Stadler, L.,Winter, G.,Holliger, P. (登録日: 2014-07-01, 公開日: 2015-02-04, 最終更新日: 2023-12-20)

• 主引用文献: Luzi, S.,Kondo, Y.,Bernard, E.,Stadler, L.K.,Vaysburd, M.,Winter, G.,Holliger, P.; Subunit disassembly and inhibition of TNF alpha by a semi-synthetic bicyclic peptide.; Protein Eng.Des.Sel., 28:45-52, 2015; PubMed: 25614525; DOI: 10.1093/protein/gzu055

実験手法

X-RAY DIFFRACTION (2.85 Å)