4TVO

Structure of Malate Dehydrogenase from Mycobacterium tuberculosis

Summary for 4TVO

• Entry DOI: 10.2210/pdb4tvo/pdb
• Descriptor: Malate dehydrogenase, SULFATE ION, SODIUM ION, ... (4 entities in total)
• Functional Keywords: krebs cycle, oxidoreductase
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 69479.27

Authors

Ferraris, D.M.,Rizzi, M. (deposition date: 2014-06-27, release date: 2015-01-14, Last modification date: 2024-05-08)

Primary citation

Ferraris, D.M.,Spallek, R.,Oehlmann, W.,Singh, M.,Rizzi, M.
Structures of citrate synthase and malate dehydrogenase of Mycobacterium tuberculosis.
Proteins, 83:389-394, 2015

PubMed Abstract: The tricarboxylic acid (TCA) cycle is a central metabolic pathway of all aerobic organisms and is responsible for the synthesis of many important precursors and molecules. TCA cycle plays a key role in the metabolism of Mycobacterium tuberculosis and is involved in the adaptation process of the bacteria to the host immune response. We present here the first crystal structures of M. tuberculosis malate dehydrogenase and citrate synthase, two consecutive enzymes of the TCA, at 2.6 Å and 1.5 Å resolution, respectively. General analogies and local differences with the previously reported homologous protein structures are described.

PubMed: 25524525
DOI: 10.1002/prot.24743

Experimental method

X-RAY DIFFRACTION (1.5 Å)